Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

N Murphy; R Carreras-Torres; M Song; AT Chan; RM Martin; N Papadimitriou; N Dimou; KK Tsilidis; B Banbury; KE Bradbury; J Besevic; S Rinaldi; E Riboli; AJ Cross; RC Travis; C Agnoli; D Albanes; SI Berndt; S Bézieau; DT Bishop; H Brenner; DD Buchanan; NC Onland-Moret; A Burnett-Hartman; PT Campbell; G Casey; S Castellví-Bel; J Chang-Claude; MD Chirlaque; A de la Chapelle; D English; JC Figueiredo; SJ Gallinger; GG Giles; SB Gruber; A Gsur; J Hampe; H Hampel; TA Harrison; M Hoffmeister; L Hsu; WY Huang; JR Huyghe; MA Jenkins; TO Keku; T Kühn; SS Kweon; L Le Marchand; CI Li; L Li; A Lindblom; V Martín; RL Milne; V Moreno; PA Newcomb; K Offit; S Ogino; J Ose; V Perduca; AI Phipps; EA Platz; JD Potter; C Qu; G Rennert; LC Sakoda; C Schafmayer; RE Schoen; ML Slattery; CM Tangen; CM Ulrich; FJB van Duijnhoven; B Van Guelpen; K Visvanathan; P Vodicka; L Vodickova; V Vymetalkova; H Wang; E White; A Wolk; MO Woods; AH Wu; W Zheng; U Peters; MJ Gunter

Journal article

Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

N Murphy, R Carreras-Torres, M Song, AT Chan, RM Martin, N Papadimitriou, N Dimou, KK Tsilidis, B Banbury, KE Bradbury, J Besevic, S Rinaldi, E Riboli, AJ Cross, RC Travis, C Agnoli, D Albanes, SI Berndt, S Bézieau, DT Bishop Show all

Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2020

DOI: 10.1053/j.gastro.2019.12.020

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Abstract

Background & Aims: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with colorectal cancer development. Methods: Serum levels of IGF1 were measured in blood samples collected from 397,380 participants from the UK Biobank, from 2006 through 2010. Incident cancer cases and cancer cases recorded first in death certificates were identified through linkage to n..

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Daniel Buchanan Author

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Graham Giles Author

Mark Jenkins Author

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Funding Acknowledgements

RMM was supported by the NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research, or the Department of Health.